About Promethazine

Prometazine is an antihistamine drug. It is used for symptomatic treatment of allergic diseases. Earlier it was also used for potentiation of anesthesia. Promethazine is used in the treatment of allergic diseases (urticaria, serum sickness, hay fever, etc.). ), in vasomotor and allergic rhinitis, in rheumatism with a pronounced allergic component, in allergic complications caused by penicillin, streptomycin and other drugs, as well as in itching dermatosis, Meniere’s disease, chorea, encephalitis and other CNS diseases accompanied by increased vascular permeability, sea and air disease. In surgical practice promethazine is used as one of the main components of lytic mixtures used for potentiated anesthesia and hypothermia, for prevention and reduction of postoperative complications, during surgery and in the postoperative period. It is also used to enhance the effects of analgesics and local anesthetics.

About Promethazine

When administered orally for adults, the daily dose is 75-100 mg. Maximal doses: when administered orally, single dose is 75 mg, daily dose is 500 mg; when administered intravenously, single dose is 50 mg, daily dose is 250 mg. V/v is used as part of lytic mixtures. Orally in children aged 1 to 2 years – 5-10 mg 1-2 times daily, 2 to 5 years – 5-10 mg 1-3 times daily, 5 to 10 years – 5-15 mg 1-3 times daily, over 10 years and adolescents 5-20 mg 1-3 times daily. When administered intravenously, the dose is 0.5-1 mg/kg, and the number of times a day is 3-5 times. In emergency cases (asthmatic status, false croup) the dose may be increased to 1-2 mg/kg. When administered intravenously (usually as part of a lytic cocktail), the dose is 1/3 of the dose for intravenous administration.

Side effects:

Digestive system: moderately pronounced numbness of the oral mucosa, dry mouth, nausea, constipation, diarrhea, discomfort; rarely – jaundice.

CNS and peripheral nervous system: drowsiness, dizziness, anxiety, lethargy, fatigue, movement coordination disorders, visual disturbances; rarely – tinnitus, euphoria, nervousness, insomnia, seizures, oculogyric crisis, catatonic status, hysteria, psychomotor agitation, extrapyramidal disorders, headache, nystagmus.

Cardiovascular system: rarely – tachycardia, bradycardia, palpitation, syncope, arterial hypotension (when injected intravenously), arrhythmias.

About Promethazine

Dermatological reactions: rare – contact dermatitis, photosensitization, urticaria.

Blood system: rare – leukopenia, agranulocytosis, aplastic anemia, thrombocytopenic purpura.

Allergic reactions: rare – exanthema, urticaria, angioedema, anaphylactic reactions.

Other: rare – irregular breathing, urinary retention.

Local reactions: painful infiltrates may occur when administered v/m.

Promethazine has an irritant effect and may cause dermatitis and irritation of mucous membranes. The same precautions as for aminazine must be observed when working with promethazine (diprazine).


Promethazine should not be prescribed for pruritus and other allergic reactions caused by the use of phenothiazine drugs (aminazine, etc.), since promethazine itself is a drug of this chemical group.

Due to its sedative effect, Prometazine should not be prescribed for drivers and other persons whose profession requires rapid mental and motor reactions.