Promethazine capillary permeability, swelling of the mucous membranes

Clinical Pharmacology
Pharmacological action – antihistamine, anti-allergic, sedative, sleeping pills, anti-emetics, mesoanesthetic, antipruritic.

Competitively blocks H 1 -histamine receptors, has antiexudative, anti-allergic, anti-inflammatory, mesto anesthetic.

Reduces capillary permeability, swelling of the mucous membranes, itching. Has adrenolytic, moderate peripheral and central cholinolytic action. Inhibits histamine-N-methyltransferase, blocks the Promethazine Therapeutic indications central histamine H 3-receptors. It inhibits CNS, has sedative, anxiolytic, antipsychotic and sleeping pills effect, lowers body temperature.

Reduces the excitability of vestibular receptors, depresses the function of the labyrinth, eliminates dizziness. Antiemetizing effect due to blockage of the receptors of the chemoreceptor zone of the elongated brain. It penetrates through GB. If administered 2 weeks before delivery, it may depress platelet Dmitry Sazonov aggregation in newborns. In experimental studies, no mutagenic effect and adverse effects on fetal development were found.

Pharmacokinetics .
Quickly and completely absorbed from the GIT. During ingestion, the effects appear after 15-60 minutes, after 20 minutes for w/m injection, after 5 minutes for w/m injection.

Duration of action – 4-6 hours (after ingestion – up to 12 hours). It is associated with plasma proteins by 65-90%. Metabolized in the liver and partially in the kidneys, with the formation of sulfides promethazine, N-demethylprometazine and other derivatives. T 1/2 – 7-14 hours. It is derived mainly from urine, including in the form of metabolites.

Indications for use
Exudative diathesis.
Rash and other skin allergic reactions to medicinal and chemical preparations.
Allergic conjunctivitis.
Whey disease.
Angioneurotic edema.
False croup.
Asthmatic bronchitis.
Atopic bronchial asthma.
Anaphylactic and anaphylactoid reactions (as part of complex therapy).
Rheumatism with pronounced allergic component.
Meniere syndrome.
Dizziness .
Nausea and vomiting .
Syndrome of motion sickness.
Neuroses and neurosis-like conditions.
Extrapyramid disorders (against the background of neuroleptics).
Neuralgia of trigeminal nerve.
Glee club.
Premedication and postoperative period (as a sedative, for artificial hibernation, potentiation of anesthesia and local anesthesia).
Study of gastric secretion (when used as a stimulant for histamine secretion).